Sentence examples for reduction responsiveness from inspiring English sources

Biomimic hyaluronic acid (HA) prodrug micelles with pH and reduction responsiveness were prepared by chemical graft of phosphorylcholine and doxorubicin (DOX) to the backbone of HA.

Additionally fluorescence microscopy measurements and MTT assay demonstrated that the micelles exhibited a faster drug release and higher cellular proliferation inhibition due to the effect of intracellular reduction responsiveness compared with that of diblock copolymers.

In addition, increased oxidative stress is related to severity of asthma, propagation of inflammatory response and reduction of responsiveness to corticosteroids.

Late-onset diabetes results from an impaired release of insulin by the pancreas and a reduction in responsiveness of body tissues to insulin that lead to the inability to metabolize sugars and fats properly.

In addition, a small buffer size PI will cause a reduction in responsiveness.

Withdrawal furthermore induces supersensitivity of serotoninergic neurons (Baumann and Rothman 1998), a transient decrease in norepinephrine (NE) in the hypothalamus, and a reduction in responsiveness to amphetamine in terms of DA concentrations in caudate-putamen and nucleus accumbens (Paulson et al. 1991).

The observed decreased growth capacity of Fp with increasing age could result from a reduction of responsiveness to mitogenic factors, as previously suggested [24].

In the immune system, senescence is associated with a dramatic reduction in responsiveness and functional dysregulation.

It has been recently suggested that this reduction in responsiveness does not occur at the stage where osteocytes respond to strain but at the subsequent stage where osteoblasts proliferate [8].

Unfortunately, once the capsaicin receptor (TRPV1) was recognized as a unique molecule entity, the psychophysical use of 'desensitization' evolved into pharmacological use, which denotes the reduction of responsiveness of receptors, ion channels, or intracellular signalling pathways after prolonged or repeated agonist exposures.

An important unanswered question is whether the reduced sensitivity to gene induction in affected populations is specific to CYP1A or a small subset of AHR target genes or, alternatively, reflects a global (i.e. genome-wide) reduction in responsiveness to all AHR-mediated changes in gene expression.