Because cefepime is predominantly renally excreted (85% unchanged), a reduction in renal function confers a proportional increase in the elimination half-life and reduction in total body clearance of cefepime [ 1].
In contrast, the reduction in renal function has been previously observed as a decrease of para-aminohippurate clearance and an increase of cystatin C in nondiabetic subjects (10).
Conclusion: A reduction in renal function and a moderate to severe dilation of upper urinary tract frequently occur in patients with ovarian cancer at the time of the diagnosis.
This orchestra of the response to sepsis leads to perilous reduction of renal function.
This reduction in renal function was associated with an increase in the renal production of TXB2, PGE2, and 6-PGF1 alpha in vitro.
In the present experimental setup, we investigated the functional outcome following a severe ischemia time of 40 min. In scid beige mice, this extent of injury resulted in a comparatively moderate reduction of renal function.
Lithium use is associated with increased risk of reduced urinary concentrating ability, hypothyroidism, hyperparathyroidism, and weight gain; however, there is little evidence for a clinically significant reduction in renal function in most patients, and the risk of end-stage renal failure is low (McKnight et al. [2012]).
Due to reduction in renal function and severity of proteinuria, immunosuppression was immediately started.
Severe kidney disease: diabetic nephropathy, important reduction of renal function (glomerular filtration rate <30 mL/min).
Renal hypertrophy has been postulated to cause a progressive reduction in renal function (Yoshida et al., 1989).
In addition, patients with a slow reduction of renal function may have been missed by the AKIN criteria [ 25].
