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The initial treatment plan required reduction or modification in 35 (34%) patients.
Methods employed previously to identify HNE adducts of proteins or amino acids, using NaBH4 reduction or modification by 3,5-dinitrophenylhydrazine, are harsh and may reflect only a fraction of the adducts formed.
Patients should be subdivided into those needing more intense immunosuppressive treatment because of their kidney disease and those needing dose reduction or modification of their medication because of their kidney disease.
Mozaffarian et al 9 investigated the effects of increasing PUFA in replacement of SFA, and observed a significant decrease in the risk of CHD or associated mortality rates, while Hooper et al 10 reported a reduction in cardiovascular risk subsequent to a long-term reduction or modification in dietary fat intake.
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Drug-induced peripheral neuropathy (DIPN) is a common but unintended effect of many lifesaving drugs and often leads to dose reduction or regimen modification that may compromise clinical outcomes.
In what concerns the short term effects though, these appear to be easily managed by transient dosage reduction or diet modifications.
Three serious AEs were considered related to treatment (anemia, neutropenia, and erythema); all resolved following treatment discontinuation, dose reduction, or without treatment modification.
Studies that allowed individual co-interventions, in addition to the intervention formally studied were deemed eligible, but those with multimodal interventions (such as mindfulness-based stress reduction or comprehensive lifestyle modification) were not, even if the latter included yoga.
Therefore, there has been growing interest in developing accurate ways of identifying individuals who have an increased risk of developing symptomatic AD so that they can be targeted for preventive interventions such as risk factor reduction, behavioral modification, or pharmacologic treatment.
When medical records contained no medical reason that could predetermine platinum dose reduction or chemotherapy delay, such modification was considered to have no objective medical reason.
We consider the following classes of host modifiers: (a) enhancement or reduction of Wolbachia modification of sperm, (b) enhancement or reduction of Wolbachia transmission to eggs, and (c) "mimicry" of egg rescue or sperm modification.
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