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In addition, our investigation of liver tissue revealed a mitochondrial import defect, which primarily affected preproteins targeted to the matrix compartment, indicating that the reduction of translocation efficiency was not solely caused by a reduced inner membrane potential.
As shown in Figure 6B, exoproteome was found to cause reduction of translocation of the canonical NF-κB; interestingly, the noncanonical form of NF-κB previously found to be involved in induction of chemokines but not inflammatory cytokines by Leishmania [4], was observed to be induced.
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This suggests that there exists a mechanism preventing the reduction of alkaloid translocation in the root.
These findings are also in line with the bacterial translocation theory of atherosclerosis, considering that both, bifidobacteria and breast-feeding, are well-known for their gut barrier fortifying effects and reduction of bacterial translocation (Lievin et al. 2000).
Addition of sewage sludge and irrigation with wastewater led to a reduction of pesticide translocation to the aerial plant parts, representing a lower hazard to ryegrass quality grown in this mine soil.
As MSP68 does not affect the oxidative burst activity of peritoneal neutrophils, its reduction of bacterial translocation is most likely an indirect effect.
This could be interpreted as meaning that the chosen probiotic bacteria are intrinsically unable to exert the hypothesized downstream effects, that is, reduction of microbial translocation and immune activation.
Another significant finding showed that EGCG, the chief polyphenol of green tea, attenuated the excessive expression of CTGF induced by abdominal aortic constriction (AAC) or AngII and also showed role in the reduction of nuclear translocation of NF- κB p65 subunit and degradation of I κB- α [ 67].
In conditions where around 90% of endogenous protein was depleted (Figure 2A), a massive reduction of p65 nuclear translocation was observed (Figures 2B and 2C).
As for the role of shoot-borne cytokinin in roots, impairing phloem transport destabilizes root vascular development with an accompanying reduction of basipetal cytokinin translocation in Arabidopsis [ 37].
The molecular basis for this partial reduction of EpICD nuclear translocation and its potential implication in the regulation of EpCAM effects are totally unclear and deserve further research.
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