Sentence examples for reduction of trail from inspiring English sources
With regard to TRAIL expression, immunofluorescent data confirmed those obtained with western blotting, showing an increase in TRAIL expression when rats were subjected to harmful ischemia (100 min tMCAO), and a substantial reduction of TRAIL expression when the animals were exposed to PC or to PC followed by tMCAO.
However, transfection of NCI-H460 cells with pre-miRs-221 and -222 caused a significant reduction of TRAIL-mediated cell death machinery activation.
Silencing of CASP8 resulted in a significant reduction of TRAIL-induced caspase-8 and -3/7 activities, similar to the level of untreated cells.
Furthermore, the fact that nystatin, a cholesterol-sequestering agent, can partially prevent TRAIL receptor localization into lipid microdomains and consequently reduce TRAIL-induced apoptosis in NSCLC cells appears in agreement with our data indicating a significant reduction of TRAIL-induced apoptosis by using the raft disruptor MBC.
Thus, the use of such mutants in combination with CD40 targeting principally allows further reduction of potential TRAIL-related side effects in cases where the latter and the apoptotic effect in the targeted tumor make differential use of TRAILR1 and TRAILR2.
A theoretical model is proposed in the current work to shed light on the noise-reduction mechanisms of trailing-edge serrations, which have been shown to suppress noise generated at the trailing edge due to the scattering of boundary layer pressure fluctuations.
The shIRF3_A cells showed a significant reduction in the levels of TRAIL, whereas PRKCE was modestly upregulated.
Overall, this simulation technique of dual-reflux pressure swing adsorption can serve as an effective tool for process design, cost reduction of laboratory and/or plant trails, and enhanced process understanding.
The mechanism by which activation of TRAIL signaling induces reductions in HIV viral load is uncertain.
Alternatively, induction of TRAIL signaling may promote reductions in HIV viral load through increased immune activation.
No decrease in clonogenic survival was observed in cells after silencing of c-FLIPL, whereas partial reduction of caspase-8 expression inhibited TRAIL-induced loss in clonogenic survival.
