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It is known that Drug Delivery System (DDS) is useful to remedy against tumors for the reduction of side effects and the effective dosage.
The promises of PM are better diagnoses, earlier interventions, more efficient drug development, more effective therapies, reduction of side effects of treatment and improved cost effectiveness.
However, two RCTs demonstrate that moxibution as an adjunctive therapy is more effective for reduction of side effects (from chemotherapy) than chemotherapy alone [ 19, 20], specifically for nausea and vomiting.
Here, the bio-molecular concepts of differential interventions offers effective treatment and the reduction of side effects as well as unique therapeutic items (e.g., prostheses, implants adapted as a truly individual), those enable patients to continue engaging in normal activities in a sense of "wellbeing".
Preliminary data showed that aDBS is safe and well tolerated in PD patients and decreases the amount of TEED, thus obtaining a reduction of side effects.
Controlled drug delivery has many advantages over conventional drug administration, such as reduction of side effects, maintaining a stable plasma level concentration and improving the quality of life of patients.
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Moreover, they will vary in their treatment- and health outcome preferences (e.g. length of life versus quality of life, physical and cognitive functioning, risk reduction, tolerance of side effects) [ 13– 15].
In responding patients, the response is usually dramatic but also drug- and dose-dependant, as treatment discontinuation or dose reductions because of side effects are rapidly followed by spleen increase and reappearance of constitutional symptoms.
Patients will benefit from the enhanced efficacy of pharmaceutical products and from reduction of side-effects.
These data are of further interest in terms of cost-efficacy and reduction of side-effects related to treatment, if we considered that an eRVR was observed in 44% of patients of SPRINT-2 RCT [ 2], and in 54% and 63% of ADVANCE [ 3] and ILLUMINATE [ 4] studies respectively.
Therefore, we speculate that the combination of multimodal analgesia and pre-emptive analgesia (multimodal pre-emptive analgesia) may have a better analgesic effect on pain management, reflected by an improved pain scoring, and a reduction of side-effects compared to the morphine group.
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