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No significant reduction of replication levels was observed in either assay at 4 h.
EGDΔlmo1031-1036 showed a more modest reduction of replication, thus confirming the result of a recent study on listerial glycerol metabolism [ 19].
The separation of replication origins is blocked in the absence of Smc-ScpAB but can be rescued by artificial reduction of replication fork speed.
Surprisingly, the growth and chromosome segregation defects in rich medium are suppressed by a reduction of replication fork velocity but not by partial inhibition of translation or transcription.
However, the 10-fold reduction of replication of rDEN4Δ30 and rDEN2Δ30 in SCID-HuH-7 mice, compared to that of their respective wild type parents, was similar.
Introduction of the 4995 mutation into rDEN4Δ30 resulted in a 100-fold greater reduction of replication in SCID-HuH-7 mice [ 17].
Similar(53)
On the possible route towards DRTs described in Appendix 1, the appearance of concatenation of multiple amino acid binding sites was not attributed to the reduction of the replication cost, but to the efficiency of the replication.
30, 31 We did not observe any effect of TNF-α on HCV replication, suggesting that increased virus entry does not lead to quicker sensing of HCV and reduction of viral replication.
Finally, we showed here that apoptosis induction was linked to T. whipplei replication: prevention of apoptosis by inhibiting the initiator caspases 8 and 10 resulted in a marked reduction of bacterial replication.
NKG2A blockade resulted in a significant reduction of HCV replication in livers and the serum at 1 and 2 wpi (Fig. 3e).
Treatment of both monocultures and co-cultures with IFNα resulted in the reduction of viral replication to similar extents as indicated by the reduction of secreted HBsAg, HBeAg, pgRNA, and sgRNA (Fig. 6f k).
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