Sentence examples for reduction of mutation from inspiring English sources

Fig. 7 Cumulative Cost versus Cost Reduction of mutation operator incremental strategy.

Recently, we investigated the cost reduction of mutation testing based on the identification of sufficient mutation operators [28].

In this regard, gene targeting experiments in mice have shown that mutations at A/T positions in the neighborhood of AID target "C" sites are exclusively introduced by the DNA MMR system during SHM, and that compromised MMR leads to the reduction of mutation frequencies at A/T positions in Ig genes [37].

However, when GG dinucleotides were deleted a significant reduction of mutation frequency was observed (Table 3).

However, only in the TA104 strains did overexpression of frataxin cause a significant reduction of mutation frequency.

Offspring from mutant males treated with 3 × 30 mg/kg demonstrate a reduction of mutation frequency in time.

A relative increase in C G mutations, primarily in transitions, has been described in MMR deficient mice [11] [13], [16], [24], [31], [32], [40], [41], but it is not clear if this can be explained solely by the dramatic reduction of mutations at A T sites or if there is also an absolute increase in the frequency of C G mutations.

The data show the activation of apoptosis in non-targeted lung tissues after PBIR, which suggests that bystander tissues mount a protective response, leading to reduction of mutations and prevention of further damage in bystander lung at 24 h after irradiation.

A similar analysis of the Igκ light chain locus, focusing on the Jκ5 3′‐flanking region of productively rearranged Vκ segments, yielded broadly similar conclusions (Fig.  4D and E), namely a reduction of mutations at As and Ts in the absence of uracil excision.

We next tested a gain-of-function mutation in the downstream kinase akt-1 [ 22] and a reduction-of-function mutation in daf-18 [ 23], the PIP3 3-phosphatase PTEN.

This result is consistent with the idea that eat-6 ad467 eat-6 ad467tisn-of-function mutation [10] and suggests that a low dosage of the WT gene, in contrast to a high dosage introduced by an extrachromosomal array, can correct aldicarb sensitivity of the ad467 mutation