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A reduction of infectious agent transmission in the public space can be achieved thanks to the photocatalytic properties of self-disinfecting and self-cleaning surfaces.
Furthermore, a combination of amiRNA expression and treatment of infected cells with cidofovir resulted in additive effects that manifested as a total reduction of infectious virus progeny by greater than 3 orders of magnitude.
The reduction of infectious TB cases via effective treatment appears to have had a substantial impact on transmission [27].
Furthermore, a reduction of infectious C. trachomatis EBs of more than 70% as compared to non-treated infected MEFs (Figure 1B) was found.
When tested in mice with established PR8 infection of the nose, we showed that 200 µg of the IgG preparation could lead to significant reduction of infectious virus at that site.
The reduction of infectious burden without an effort to eliminate the pathogen appears to align well with the hypothesis that mucosal immunoglobulins protect without eliciting much inflammation [36], given the expected serious consequences of strong inflammatory responses at mucosal surfaces.
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The investigation of antiviral activity of curcumin on Neuro2a cell line infected with JEV showed reduction in production of infectious viral particles through inhibition of ubiquitin-proteasome system.
In IAV-infected cells, activated caspases cleaved their substrates, such as Bid, and disrupted basic cellular pathways and functions, which resulted in an inhibition of the transcription and translation of cellular and viral mRNA and a reduction in the production of infectious IAV virions (Supplementary Figure 3).
An antibiotic prophylaxis had confirmed efficacy in the reduction of early infectious complications of PEG insertion [ 5, 8].
A chemical disinfecting agent is expected to be capable of a 3-log10 reduction of the infectious bacteria, within 30 seconds [ 6, 19].
As we argue in the Conclusions, the effect on transmission of the reduction of the infectious period of affected farms (by their detection and culling) is expected to be less important.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com