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The reduction of heterogeneity with increasing age is in agreement with a new study, which applied single-cell transcriptomics to characterize beta-cell diversity during mouse pancreas development.
In our meta-analysis presumable confounders were investigated through stratification on several factors, with a reduction of heterogeneity.
In the functional capacity plot, Chamberlain [ 19] was the outlier study and removing it from the forest plot resulted in reduction of heterogeneity.
Sequentially removing sources and examining the resulting reduction of heterogeneity in heat shock tolerance showed that the scarring and unequal division of damage processes are the predominant sources.
For DRB1*07, the ethnicity-stratified analysis showed a reduction of heterogeneity in caucasians (I = 16%) and other mixed ethnicities (I = 13%).
However, to contribute to the reduction of heterogeneity in tail length, only cells with an increased tail length would ideally be included in the measurements.
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The better glass-forming ability is linked to the reduction of heterogeneities, whereas the thermal characteristics depend on both parameters.
Therefore, the PEEP optimization strategy based on the trade-off between derecruitment and overdistension was in agreement with that based on the reduction of heterogeneities.
The reduction of humic heterogeneity obtained in HPSEC separated size-fractions suggested that their physiological influence on root growth and architecture was less an effect of their size than their content of specific bioactive molecules.
This study uses adequate methodology of systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [27], as well as providing exploration and reduction of the heterogeneity of the studies using subgroup analysis and adequate statistical analysis.
Thus, the reduction of genetic heterogeneity into clinically meaningful biological networks could have an impact in the context of personalized medicine.
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