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It is possible to transpose the damage degrees into levels of reduction of functionality (total or partial) and collapse (partial or total), and then associate an economic value that quantifies the loss.
This could indicate that these proteins may have evolved a particular structure adapted to elevated pressure because their up-regulation could compensate the reduction of functionality.
We can speculate that P. profundum, and possibly other Vibrionaceae, evolved the ability to control expression of the genes coding the "chr. 2 ATP synthase" to compensate reduction of functionality determined on the "main" ATP synthase by suboptimal environmental conditions.
Similar(57)
The overexpression of MMP2 was reported previously in several cancer tissues, and the inhibition of MMP2 function by halofuginone resulted in significant reduction of vascular functionality, decreased vascular density and less tumor size in VHL PCC in vivo models [ 76].
The reduction of ADM functionality by an anti-N-terminal antibody might be more relevant in the later phase, when excessive endogenous ADM production is associated with fatal outcome.
Nevertheless the ability of CuO NPs to induce a TEER reduction underlines the importance of better understanding the effects of NPs on the ABB in terms of reduction of its functionality.
The founder of the approach, James McCullough, suggests that chronically depressed patients suffer from a reduction of perceived functionality, i.e. the ability to detect the effects of their own behavior on other persons.
This variability is likely related to the reduction of MAP3K4 functionality to near-threshold levels, and the consequence of this for levels and timing of Sry expression during gonadogenesis.
Findings suggest that ecological restoration of highly polluted agricultural soils leads to overcoming the reduction of soil functionalities linked to Cu contamination and opens interesting perspectives for mitigating Cu stress in agricultural soils with strategies based on conservative agriculture.
Phenylcoumaran benzylic ether reductases are involved in phenolic secondary metabolism and convert 8'5′-linked lignin dihydroconiferyl alcohol into isodihydrodehydrodiconiferyl alcohol by the reduction of benzylic ether functionality (Gang et al. 1999).
Reduction reactions are less frequent, but several biotransformation paths are known, for example, nitro reduction to amine [ 144], the reduction of azo bond functionality in organic dyes leading to two aromatic amines [ 145] and ketone/aldehyde reduction to secondary/primary alcohol [ 33, 40, 56, 126].
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