Sentence examples for reduction of flexibility from inspiring English sources

If the changes introduced in albumin increase the protein stability (rigidity of the molecule), a reduction of flexibility and then a corresponding reduction in the RS component can be expected, as was observed here (Figure 9).

This distinction enables adaptation to proceed by changes of the opposite sign in ordered and disordered proteins, such as a reduction of flexibility of globular proteins by an increase in hydrophobicty and a parallel increase in structural disorder/frequency of IDPs due to a decrease in hydrophobicity.

This reduction of flexibility and adaptability could result in rigid and suboptimal decision making, learning, and memory as is seen in cases of addiction (e.g., Monterosso et al., 2012), and neurological diseases such as Alzheimer∼s and Parkinson∼s disease.

Also, it has been reported that collagen metabolism is abnormal in Marfan patients and overexpression of a collagen gene results in reduction of flexibility of extracellular matrix (ECM), thus contributing to Marfan pathology (Priest et al. 1973; Tajima 1995; Robinson et al. 2006).

This is consistent with the conclusion above that bH1-44 and Herceptin interactions are subjected to similar entropic penalties due to reduction of conformational flexibility upon antigen binding.

They were able to increase the affinity of the A6 TCR for Tax-HLAA2 by a factor of 2400 through the reduction of the flexibility of CDR3 by using proline substitutions together with other mutations.

We propose that the buffering of transcriptional regulation by balancing effects of analog and digital types of control can counteract the reduction of adaptational flexibility caused by accumulation of mutations in bacteria [ 2].

One important objection to Lamarckian evolution by inheritance of acquired characteristics emphasized by Bateson over forty years ago is the reduction of adaptational flexibility upon progressive specialization, necessitating the occurrence of genotypic changes compensating for this limitation [ 1].

For design tubular systems it is also important to consider the internal-pressure effect, given its effect on the reduction of the pipe flexibility.

Although some studies suggest that MXL models have advantages over standard logit models in terms of flexibility, reduction of standard error and inclusion of demographic characteristics [ 29], the MXL model requires a larger sample size than the CL model [ 25].

Because of the hardware and software modularity, they have the advantages such as reduction of system costs, application flexibility, system reliability, and system extensibility.