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The analysis of kinetic data (surface accumulation rate) with a transport-limited regime model suggests the reduction of diffusion coefficient (i.e. the increase of size of the adsorbent) with increasing divalent salt concentration.
Usually, on the basis of measurements of several ions in frog skeletal muscle (21), the factor of two is considered common for such a reduction of diffusion coefficient.
A reduction of diffusion coefficient by a factor larger than two has been reported for the molecules that bind to the proteins.
For example, in analysis of diffusion of fura-2 and indo-1 by bleaching, the considerably larger reduction of diffusion coefficient was explained by protein binding of the fluorescent calcium indicators (4).
Although the reduction of diffusion coefficient estimated by RICS was not as profound as the estimation found in our simulations, the differences can be attributed to the nature of diffusion restrictions.
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Thus our analysis gives overall reduction of diffusion coefficients in the rat cardiomyocytes.
Thus the reductions of diffusion coefficient in the transverse direction are probably induced by the specific organization of the cells, not protein binding.
This is close to the reduction of the diffusion coefficient by a factor of two in frog muscles compared with the value in water (21).
This was confirmed by permeation studies with six different gases, showing that the reduction of the permeability coefficient of the samples as a function of time is almost entirely due to a reduction of the diffusion coefficient.
Reduction of apparent diffusion coefficient (ADC) values in white matter is not always ischaemic in nature.
It also results very suitable for measuring concrete aging and then accounting for the reduction of the diffusion coefficient with time.
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