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Vietnam's long-term investments into strengthening of its health systems, improvements in reduction of bottlenecks in the delivery, and scaling up of interventions, were reflected in the highest possible grant assessment score (A-1) of existing GFATM HSS programs.
This finding underscores the importance of using a 'bottom up approach' for the identification and reduction of bottlenecks to improve transitional care.
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While this resulted in reduction of administrative bottlenecks, it also meant that supervision of the district was no longer done by the regions (which had been abolished), but rather the central office.
In systems biology, PSA has found wide applications, such as for model calibration and identifiability, model validation and reduction, identification of bottlenecking processes, elucidation of mechanisms of complex cellular behaviour, and investigation of cellular robustness [ 30, 33].
24 Reduction of these experienced bottlenecks may explain the improved quality of chronic care delivery over time.
This permanent reduction of genetic diversity (bottleneck) has resulted in a high incidence of specific genetic diseases in different breeds, and in some breeds most of the animals are affected or carriers [ 10].
Among these, enhancing teachers' conditions of service (improvement of teachers' salaries, prompt payment of salaries, reduction in bottlenecks in appointments, transfers and promotions; rewards and recognition for serving well in difficult areas, providing accommodation and targeting micro-finance schemes for teachers) are paramount.
Furthermore, the appearance of changes after treatment cessation in one case suggested that treatment with IFN-alpha may shift the distribution of viral populations via the reduction of viral heterogeneity through bottlenecks and/or increased T-cell pressure on the virus during therapy.
It is important to recognize that populations suffering a reduction in census size (demographic decline) may not necessarily suffer a severe reduction of Ne (a genetic bottleneck) and vice versa (Luikart et al. 1998).
Further reduction of genetic diversity occurs in bottlenecks caused by small population size of the initial colonizing population ("founder effect").
Perhaps the best-documented consequence of this selection is a reduction of variation caused by genetic bottlenecks during the domestication process and through selective sweeps due to linkage to genes that are desirable in agriculture [ 38].
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