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Three weeks later he was implanted with a >50%/<85% reduction of attack number and intensity of pain.
We observed a more relevant and faster reduction of attack frequency in patients who reached a daily dose of 150 mg even in the first month.
The significant reduction of attack frequency per month was similar (about 33%) between episodic (from 6.8 ± 3.0 to 4.8 ± 3.5) and chronic migraineurs (from 27.6 ± 5.2 to 18.7 ± 9.7).
A secondary observational endpoint was the reduction of attack frequency, established by comparing the frequency of cCH attacks per 4 weeks at the end of the experimental period to the frequency established at baseline.
In a randomized double-blind versus placebo study sumatriptan 100 mg administered three times per day for 7 days did not induce a significant reduction of attack frequency [306].
A shortened hormone-free interval, from a 21/7- to a 24/4-regimen, in women taking CHC showed a positive effect on MM with significant reduction of attack duration and pain intensity.
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Petasites hibridus: 50% reduction of attacks in 77% of cases with M in an open-label multicentre study [14].
Results A reduction of attacks by at least 30%, as compared to baseline, was observed in 12 cases (66%).
Coenzyme Q10: in CoQ10-deficient patients, CoQ10 supplementation obtained a reduction of attacks' frequency and disability degree [10].
We start the treatment with sodium valproate up to 1500 mg/d and after one month the patient had a significant reduction of attacks and their severity.
The following evidences are available in the literature: Petasites hibridus: 50% reduction of attacks in 77% of cases with M in an open-label multicentre study [14].
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