Here, the inactivation of an early cis-regulatory element by a binding site mutation does not abolish expression, but only delays it until late cis elements are activated and compensate for the reduction of activity of the URE.
This part of the brain activates when anticipating pain relief and triggers a reduction of activity in pain-sensing areas of the brain.
Here, reduced activation in pre-motor areas was combined with a reduction of activity in parietal areas.
At the same time, the researchers also noticed a significant reduction of activity in brain regions involved in visual processing and memory during 'no go' trials compared to 'Go' trials.
When these structural changes were both introduced, a dramatic reduction of activity was observed for both N1 and N3.
In the middle panel of this figure, we plotted a two-dimensional simplification of the left DLPFC's 745-dimensional space (745 voxels; ×4 condition) based on a multidimensional scaling (MDS) dimensionality reduction of activity patterns in this region.
Conversion of residue 23 to DNA led to a reduction of activity by 50%, whereas conversion of residues 16 or 24 to DNA led to an almost complete ablation of activity (Fig. 2a, top).
Heat loss in humans is aided by reduction of activity, by perspiration, and by heat-exchange mechanisms that permit larger amounts of blood to circulate near the skin surface.
The scalp distribution of the group differences in P3a and the ERN is consistent with a reduction of activity of sources in dorsal anterior cingulate cortex (dACC), suggesting a global deficit in cognitive control operations subserved by dACC in ADHD.
Kidney uptake seems to be affected as well, as 68Ga-Ex4NOD12 shows a reduction of activity over time while the other two radiolabelled peptides seem to accumulate.
By doing so, GA can inhibit the glucocorticoid-induced signalling cascades, resulting in the reduction of activity of the rate-limiting gluconeogenic enzyme, phosphoenolpyruate carboxykinase, in the liver and kidney [9].
