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Surgical treatments should be avoided, especially in children, as they are all burdened by a reduction in visual function.
However, most patients require multiple retreatments and collateral damage to adjacent healthy tissues may occur with resultant reduction in visual function (Reinke et al 1999).
Similarly, the histological examination of retinas from cep290 MO-injected zebrafish revealed no gross lamination defects, yet the embryos had a statistically significant reduction in visual function.
Vision loss or impairment is also now being studied in mice and rats using the optokinetic response (Thomas et al., 2010); investigating the cause of a diabetes-induced reduction in visual function might provide new insight into the causes of vision loss in diabetic humans.
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These findings have been corroborated in vivo by OCT, demonstrating thinning of the GCL + IPL, and associated with reductions in visual function and vision-specific quality of life (Syc et al., 2012; Walter et al., 2012).
The degree of reduction of the cone density was correlated with the decrease in visual function measured by multifocal electroretinography (mfERG) [ 9, 11, 12].
Despite the significant improvement in visual function, reduction in ICP, papilloedema, BMI and reduction in weight during the dietary intervention, none of these measures correlated with the improvement in QOL scores (Additional file 2).
However, the improvement in visual function is likely to have been due to a neuroenhancing effect of IOP reduction.
The patient reports no impairment in visual function.
Study has reported that improvement in visual function is directly related to improvement in visual acuity [ 9].
Although the notable reduction in the visual function threshold for cataract surgery was due to improvements in the provision of cataract surgery, methodological challenges in measuring post surgical outcomes rendered it impossible to conclude whether overutilization was indeed occurring [ 12].
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