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In AMD, the reduction in visual field sensitivity is most pronounced in the foveal region (Fig. 5A).
To assess the relationship between the reduction in visual field sensitivity and changes in cortical grey matter density, for each group, mean sensitivity deviation maps were calculated.
However, a reduction in visual field sensitivity is linked to retinal ganglion cell loss and not to other components of the neuro-retina (Garway-Heath et al., 2000; Swanson et al., 2004).
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In glaucoma, the main reductions in visual field sensitivity are located more peripherally (Fig. 5B).
In one study involving rhesus monkeys with unilateral laser-induced experimental glaucoma, Harwerth and colleagues found reductions in visual field sensitivity could be present without apparent retinal ganglion cell loss on histology [ 23, 24].
Investigator assessments revealed no significant association between IOP reduction over two years and change in visual field.
Retinotopically, the pattern of grey matter reduction that we find in our study correlates well with the pattern of changes in visual field sensitivity in both types of pathology.
No progressive "clusters" could be found in visual field series of 14 eyes (34%, 81 visual field examinations).
In the majority of cases, patients carrying mutations in GUCA1A have little or no reduction in peripheral visual field and night vision, but experience marked photophobia and significantly impaired colour vision and visual acuity – consistent with the sparing of rod function and the classification of disease as a cone dystrophy.
This eliminates the symptom, but at the cost of creating another: a reduction in the visual field between 48%and76%6%. 1 Crucially, while we do not use the peripheral visual field for exploratory vision, its sharp temporal sensitivity is key to navigating in response to sudden events. 2 Many patients find its loss unsettling, sometimes as much as the diplopia itself.
PURPOSE: To determine whether the ability to document improvement in visual fields after intraocular pressure (IOP) reduction can be enhanced by focusing on regions of the field with different levels of sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com