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Late-onset diabetes results from an impaired release of insulin by the pancreas and a reduction in responsiveness of body tissues to insulin that lead to the inability to metabolize sugars and fats properly.
In addition, a small buffer size PI will cause a reduction in responsiveness.
Withdrawal furthermore induces supersensitivity of serotoninergic neurons (Baumann and Rothman 1998), a transient decrease in norepinephrine (NE) in the hypothalamus, and a reduction in responsiveness to amphetamine in terms of DA concentrations in caudate-putamen and nucleus accumbens (Paulson et al. 1991).
In the immune system, senescence is associated with a dramatic reduction in responsiveness and functional dysregulation.
It has been recently suggested that this reduction in responsiveness does not occur at the stage where osteocytes respond to strain but at the subsequent stage where osteoblasts proliferate [8].
An important unanswered question is whether the reduced sensitivity to gene induction in affected populations is specific to CYP1A or a small subset of AHR target genes or, alternatively, reflects a global (i.e. genome-wide) reduction in responsiveness to all AHR-mediated changes in gene expression.
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We implement adaptation as a change in the likelihood function (i.e., the sensory evidence), reflecting that neurons show orientation specific reductions in responsiveness to repeated stimuli.
Reductions in responsiveness to male courtship are often associated with an increase in the importance of sneak copulations relative to courtship-choice copulations [ 7, 9, 10], and thus a reduction in the sexual selection imposed by mate choice.
In the behavioral paradigm, the HMF chicks had a higher elimination rate than the GMF chicks and displayed a significant reduction in overall responsiveness.
The similarities between sleep and anaesthesia include: a subjective loss of consciousness, reduced sensory awareness, and a reduction in behavioural responsiveness.
The fact that decreased response to TUT in repeaters is unlikely to be due to a non-specific reduction in auditory responsiveness to sound or to songbird vocalizations, in general, is supported by an additional result.
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