Sentence examples for reduction in replication from inspiring English sources

The slight reduction in replication fidelity of this ITR with respect to wt ITR5 may signal the inability Rep to properly interact with the RBE' [4].

Hassaïne et al. [44] found that the precise amino acid signature Ser132Arg in Vif correlated with a five-fold reduction in replication in long term nonprogressor.

Reduction in replication activity (increased plasmid loss rate values) was observed after mutation of one ACS motif (R2), and of both motifs (R2+R1) in NUMT2; in the last case a few colonies did grow (pRS405 and pRS405-CEN), indicating that additional elements play a role in replication efficiency [26].

Overexpression of these proteins resulted in a significant decrease in the growth rate of the cells compared to vector starting from day 1 in both cell lines (Figure 5B), which correlated with dramatic reduction in replication potential in RKO cells expressing TBX18 or HOXB13 compared to vector transfected cells (Figure 5C).

In the present study, we have analyzed these mutations and show that 3 of the 6 mutations (in the 3'NTR and NS5A coding sequence) are both necessary and sufficient for a robust, wild-type-like viral replication phenotype in vivo, and thus presumably compensate for a reduction in replication fitness imposed by the chimeric HCV sequences within domain III of the 5'NTR.

Although rDEN2Δ30 was slightly attenuated compared to its DEN-2 parent virus in rhesus monkeys, the reduction in replication was less than that of rDEN1Δ30 and rDEN4Δ30.

Significant restriction was seen in all cases, most notably for HIV-1 cores pseudotyped with VSV-G, for which 4-5-log reductions in replication were observed (Fig. 3b).

The specific and marked reduction in viral replication against rapidly replicating Chikungunya virus achieved in this study offers a potential new therapeutic approach.

Of primary importance, knockdown of pn led to significant reduction in mtDNA replication in gap phases, demonstrating that Pn promotes mtDNA replication (Fig 1B and C).

However, the replication of HVR deletion mutants was markedly reduced in Huh7 cells, and a similar reduction in HEV replication was observed when HVR deletion mutants from avian HEV were tested in LMH chicken liver cells.

Despite their diversity of replication and translation mechanisms, each showed a similar relationship between the extent of CPD and reduction in virus replication ability (Table 1).