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Post-hoc analysis showed that the reduction in outcomes was similar in the medium and larger projects (p = 0.875).
Heyland et al. showed in a meta-analysis that antioxidants, particularly high-dose intravenous selenite, as monotherapy or in combination with other antioxidants, are a safe strategy and are associated with a trend toward reduction in outcomes, including mortality [ 5].
The study showed a reduction in both treatment 'failure' (RR = 0.54; 95% CI 0.32, 0.91) and the rate of up-transfer (RR = 0.51; 95% CI 0.31, 0.89), but did not show any statistically significant reduction in outcomes such as length of admission.
This association was, however, no longer detectable in models adjusted for changes in low density lipoprotein cholesterol (bivariable or multivariable), indicating that the apparent reduction in outcomes was due to the association of changes in high density lipoprotein cholesterol with changes in low density lipoprotein cholesterol.
Similar(56)
Reduction in toxicity may lead to improved quality of life without the reduction in outcome.
The reduction in outcome-relevant behavioral variability is correlated with a concomitant reduction in M1/DS neuronal activity variability over learning blocks, and abolished in mice with deficient corticostriatal plasticity.
The authors found that adjusting breast cancer expression data for this cell proliferation signature causes a dramatic reduction in outcome association of most published breast cancer signatures (Venet et al., 2011).
The study found that, compared to placebo (inactive medication), supplementation did not bring significant reductions in outcomes 2 or 3.
Overall, reductions in outcomes measured between the low primary care group and the medium group were substantial.
42 Additionally, there are theoretical considerations that include the fact that in health disparities research, stringent goals, for example, complete glycaemic control, may not be realised and one may consider smaller average reductions in outcomes as clinically meaningful.
Who cares if there is sizeable and growing body of rigorous empirical literature validating that state school finance reforms can have substantive, positive effects on student outcomes, including reductions in outcome disparities or increases in overall outcome levels?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com