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The reduction in invasive testing also means there will be a reduction in miscarriages and loss of unaffected babies, which is much better for parents".
In terms of standard deviations, the reduction of a one standard deviation increase in program coverage implies roughly a one percentage point (or slightly less than 10%%) reduction in miscarriages.
Conclusion: The implementation of combination treatment of folic acid, doxycycline, low dose aspirin and natural progesterone resulted in a significant increase in the live birth rate, a significant reduction in miscarriages, and lower incidence of complications in patients with recurrent early pregnancy loss.
Both studies showed a reduction in miscarriage rates (36%and75%5% relative reductions), and when the results were pooled, there was a significant 52% relative risk reduction in miscarriages with levothyroxine (0.48, 0.25 to 0.92; P=0.03) (fig 7).
Both showed a fall in miscarriage rates, and meta-analysis showed a significant 52% relative risk reduction in miscarriages with levothyroxine (relative risk 0.48, 0.25 to 0.92; P=0.92).
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In addition, this study found a significant reduction in miscarriage rates amongst those women receiving acupuncture treatment (p < 0.05).
In a multicentre clinical trial, Worrilow et al. (2013) showed that pre-screened and selected patients with <65% HA binding efficiency before ICSI, exhibited slightly higher success rates with the use of this technology, but a significant reduction in miscarriage rates (3.3 versus 15.1% in controls).
Only one study reported fetal loss (miscarriage and stillbirth) and indicated a reduction in stillbirth with multi-vitamin supplementation among HIV-infected women in pregnancy (30/512 in supplemented groups versus 49/509 in controls (RR 0.61, 95% CI 0.39-0.94) [ 137].
They include a reduction in risk of miscarriage, as well as mitigation of (or protection against) low birth weight, neonatal and maternal death, preterm birth, and anaemia.
Pooled analysis of five trials reported a significant 32% reduction in foetal loss (miscarriage or stillbirths) (RR 0.68; 95% CI: 0.48, 0.98) (Gamble et al., 2006).
A subset of those trials pooled in the Cochrane review reported a significant 32% reduction in foetal loss (miscarriage or stillbirths) (RR 0.68; 95% CI: 0.48, 0.89; three studies, n = 4557) (Gamble et al., 2007).
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