Surprisingly, even double mutants, lacking both mitochondrial forms of SOD, show no reduction in lifespan.
Even sod-2/sod-3 double mutants, entirely deficient in mitochondrial SOD, show no reduction in lifespan.
The wMelPop-CLA strain dramatically reduces mosquito fitness through reduction in lifespan [6] and impaired probing and feeding [26], [27].
This ability to preserve HIV-1-specific effector T cells may not be permanent, and a reduction in lifespan of T cells may precede disease progression.
Knowledge of factors affecting sand fly longevity that lead to a reduction in lifespan could result in a decrease in parasite transmission.
Through deletion of the C3G locus, we have observed that loss of C3G causes semi-lethality, and that escaping adult flies are characterized by a reduction in lifespan and general fitness.
We also assessed aging in these animals and found a significant reduction in lifespan under nutrient-rich conditions (Figure S5), although reduced AMPK function did not significantly impact lifespan for younger cohorts used for starvation studies.
One of the major results from these mutants, with respect to the mFRTA, was a surprising lack of reduction in lifespan in response to single and even multiple deletion of SOD genes [28] [30].
