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Needed are prospective controlled studies to better understand the effects of a mild reduction in kidney function from kidney donation in otherwise healthy individuals.
Based on the Acute Kidney Injury Network, AKI was defined as an abrupt (within 48 h) reduction in kidney function, defined as an absolute increase in serum creatinine concentration of 0.3 mg/dL (26.4 µmol/L) or greater or a percentage increase of 50% or greater (1.5-fold from baseline).
reduction in kidney function currently defined as an absolute increase in serum creatinine of more than or equal to 0.3 mg/dl, or1.5 fold from baseline or a reduction in urine output (documented oliguria of < 0.5 ml/kg per hr. for >6 hr).
Participants with eGFR <60 mL/min/1.73 m were classified with moderate or severe reduction in kidney function, and participants with eGFR ≥60 mL/min/1.73 m were classified with normal or mild reduction in kidney function.
Some patients develop a chronic reduction in kidney function or a permanent need for renal replacement therapy.
PFAAs are associated with a reduction in kidney function and increased uric acid levels in otherwise healthy adolescents.
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This finding should encourage initiatives towards developing prophylactic strategies for patients who develop even mild reductions in kidney function.
Upon examining further reductions in kidney function (eGFR < 60), the association of high-risk APOL1 and reduced kidney function was significant.
Even mild reductions in kidney function can alter the electrophysiological properties of the myocardium and increase the risk of ventricular arrhythmias and sudden cardiac death.
We have, however, used several measures to capture patients designated with acute reductions in kidney function consistent with the syndrome of AKI.
Approximately 50% of the absorbed dose of a bisphosphonate is excreted unchanged by the kidney; therefore, reductions in kidney function have the potential to result in accumulation of the bisphosphonate.
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