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A consequent reduction in Gem dose was required.
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Consistent with the phenotype, the GL2 expression has been observed to increase in gem-1 whereas decrease in GEM-overexpressing plants (Caro, et al. 2007).
As such, the observed reduction in ttk expression after Gem overexpression can be interpreted as a premature neuronal transformation of secondary precursor cells.
Of note, the lack of a significant reduction in tumor growth by Gem alone in the present study is likely merely a result of the small number of animals in that tumor growth experiment, and does not pose a conflict with the significant improvement in animal survival seen after the same treatment.
The tumor-bearing mice first treated with Gem followed by 5/3COX2CRAdF showed a significant reduction in tumor size compared to Gem alone after 12 days (P = 0.014).
On the other hand, reduction in FUS/TLS leads to abnormality in Gems, nuclear granules marked by SMN1 that is involved in the assembly of small nuclear ribonucleoprotein particles and implicated in a motor neuron disease [ 9, 10].
No significant changes were observed in Gem.
Palmitoylation supports anchoring in GEM [ 16, 17].
We concluded that cld7 is preferentially located in GEM and recruits EpC into GEM.
Proteins located in GEM are recovered in fractions 2 4.
One patient receiving Gem experienced a PR and had a 52% reduction in CA 19-9 levels during treatment.
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