Sentence examples for reduction in functionality from inspiring English sources

However, it also leads to a reduction in functionality of the enhanced system.

Someone needs to remind the marketing folks that if the user is encouraged to close their eyes, this instantly becomes only a 3 Senses Lounger, a 25% reduction in functionality!

As a general principle immortalization by overexpression of hTERT only, minimises the reduction in functionality [ 12].

One of the associated SNPs, rs6721961, which showed a minor allele frequency of 11.1 % in this sample, was located in the promoter region of the gene, and its T-allele had been previously linked to a reduction in functionality that limited the NFE2L2 triggering of the antioxidative response [ 9].

Although the elevated levels of fasting glucose and impairment of insulin action in peripheral tissues may predate the diagnosis of type 2 diabetes, chronic hyperglycemia only results after a prolonged period of β-cell degeneration, a process that may begin as much as 12 years before diagnosis, involving a progressive reduction in functionality and mass (1, 2).

Mammalian aging is associated with a reduction in organismal functionality and this is accompanied by an age-related decline in tissue regeneration and homoeostasis [ 11, 13, 14, 68].

Since the exposure of human osteoblasts to both drugs did not result in a cytotoxic affect in this study, a downregulation of BMP-2 signalling may explain the reduction in osteoblast functionality.

In all cases the reduction in the functionality of these proteins results in a decrease in the processing efficiency of miRNA precursor transcripts (pri- and pre-miRNA) and in a decrease in the amount of mature molecules [ 1, 6, 7, 32, 34].

A reduction in frequency and functionality of CD56bright NK cells has been observed in patients with active tuberculosis and reciprocally, high blood levels were associated with protection in putative tuberculosis-resistant individuals.

Since CD8+ cytotoxic T cells are important in the containment of HIV replication, reduction in their number and functionality associated with HIV infection and aging, coupled with loss of CD4 cells, may help explain the accelerated progression of HIV infection in older adults.

We observed impaired degranulation mostly in the mature NK cell subset of aged mice, highlighting that not only does the reduced frequency of the mature NK cell subset contribute to the overall reduction in aged NK cell functionality, but that mature NK cells in aging are also hyporesponsive.