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Despite the observed reduction in focus score, stimulated salivary flow was not improved in early treated mice.
Consistent with these observations, we found that silencing of IKKε with siRNA led to significant reduction in focus formation in both MCF-7 cells and SK-BR-3 cells.
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To mature these concepts, the project has made significant investments in technology risk reduction in focused subsystems.
These two phenotypes i.e., reduction in foci initiation and expansion will be referred to as SLIM, for suppressed leaf infection and cell-to-cell movement.
Numerous and large sized foci were detected in untreated MDCK cell culture whereas in DAS181 pre-treated monolayers, the foci were very small in size and a qualitative dose-dependent reduction in foci number was also observed.
Of these, GF 109203X only produced a reduction in foci numbers at the very highest concentration.
After 4 days of experiment, anti-adsorption activity of baicalein was determined by reduction in foci numbers as described above.
After 4 days of infection, antiviral activity was determined by reduction in foci numbers as described above.
Following the secondary screening four compounds demonstrated a significant reduction in foci number over the dilution range (Fig. 1A E).
The neutralizing antibody titer was expressed as the maximum serum dilution yielding 80% reduction in foci formed (FRNT80).
COX-2 inhibitors reduced the number of lung foci, but not as much as the reduction in foci seen in the HPK1−/− mice.
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