Sentence examples for reduction in crossover from inspiring English sources

Using this approach, we show that loss of interference in zip2 and zip4/spo22 mutants is accompanied by a reduction in crossover homeostasis, thus connecting these two levels of crossover control.

Statistically significant reduction in crossover numbers was observed on all chromosomes in the msh4 mutants.

The msh4 –R676W hypomorph shows genome-wide reduction in crossover number compared to wild type.

Defects in this gene may cause chromosomal asynapsis and reduction in crossover formation [ 35].

These results suggest SK1 MSH4 /5 genes are functional in the S288c/YJM789 hybrid with a minor reduction in crossover frequency that does not affect spore viability.

The minor reduction in crossover frequency may be because of replacement of the S288c and YJM789 MSH4 /5 alleles with the SK1 MSH4 /5 alleles.

The msh4 –R676W hypomorph showed ∼30% genome-wide reduction in crossovers and reduced crossover interference.

The reduction in crossovers compared to wild type is statistically significant for the msh4 –R676W hypomorph (t-test, P = 4.18 × 10−9).

Any reduction in crossovers through a mutation/ polymorphism or random fluctuation in crossover numbers coupled with the loss of interference therefore results in increased incidence of nonexchange pairs.

Nonexchange chromosomes are therefore expected in msh4 –R676W if the reduction in crossovers is associated with loss of interference (the Poisson distribution assumes that the crossover events are independent).

We define cold regions as long (>500 kbp) contiguous genomic intervals that have a >10-fold reduction in crossovers compared to the genome-wide average.