Sentence examples for reduction in complement from inspiring English sources
Consistent with a reduction in complement activation by the classical pathway, the HT transgenic PAC showed a 2-fold reduction in the deposition of complement components C4 and C3 relative to controls.
Overall, we expect the observed reduction in complement activity to be problematic, not only for mounting an appropriate response to an existing assault from Bd, but also for responding to future pathogenic insults.
A 90% reduction in complement levels (as determined by the CH50 assay) was also observed in post-dose serum samples (data not shown).
Similarly, administration of rhC1INH led to significant reduction in complement deposition and significant inhibition of tubular damage and tubular epithelial cells apoptosis in a swine model of renal I/R injury [ 42].
For instance, reduction in complement resistance through blockade of mCRPs has been shown to enhance the efficacy of mAb immunotherapy, which requires effective ADCC and complement-dependent cytotoxicity 93– 93.
Obinutuzumab is a novel glycoengineered type II CD20 antibody that has enhanced FcgRIII affinity resulting in superior antibody-dependent cell cytotoxicity (ADCC) and antibody dependent cell phagocytosis induction as compared with rituximab; and mediates strong direct cell-death induction with a concomitant reduction in complement dependent cytotoxicity.
A humanized variant, huKM796H/Lm-28, containing eight and five amino acid alterations in variable light (VL) and variable heavy (VH) FRs, respectively, showed a 9-fold reduction in complement-dependent cytotoxicity (CDC) compared to the chimeric KM966, despite tight antigen binding and potent antibody-dependent cellular cytotoxicity (ADCC).
The merger leads to a reduction in both complement prices, since the new firm captures the demand increase in the composite good when it lowers the other component's price.
After two ganciclovir treatments on E11, ablated mice terminated on E12 had an 84% reduction in the complement of GPT neurons normally present on E12.
After four treatments on E11 E12, ablated mice terminated on E13 had an 83% reduction in the complement of GPT neurons normally present on E13.
One possible mechanism for this observation was the possible association of RF titer with reductions in serum complement.
