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There was a significant reduction in the tissue volume for the groups collagen (Col), EGF and NGF, while only EGF had a significant reduction in bone volume.
This reduction is greatest for the experimental groups utilising a collagen membrane (Collagen, EGF and NGF) with a statistically significant reduction in tissue volume for Collagen, EGF and NGF groups while only the EGF group had a significant reduction in bone volume.
These results indicated that stimulatory effect of Cthrc1 on bone formation partly prevents reduction in bone volume by ovariectomy.
Reconstructions of the trabecular bone in distal femurs illustrated the striking reduction in bone volume in both CKO and CKOOsx mice as compared to their wildtype and heterozygous littermates (Figure 4A).
The primary effect of the tumour is the reduction in bone volume (p<0.01, Figure 7B) and consequent increase in the bone-surface area: bone-volume ratio in tumour-bearing bones (p<0.001, Figure 7C), while the ZOL treatments result in an increase in bone volumes (p<0.001, Figure 7B) and a decrease in bone-surface area: bone-volume ratio (p<0.001, Figure 7C) of tumour-bearing bones.
After treatment, bone histomorphometry showed a significant reduction in bone volume, strength and mineralisation surface compared with controls (P<0.05) (Wheeler et al, 1995).
Similar(51)
Age-related disturbances in BM microenvironmental components are hypothesized to contribute to alterations in haematopoietic competence47 and include increased adipocyte infiltration48, perturbations of the cytokine milieu and reductions in bone volume and type H vessels15.
These reductions in bone volume and cortical thickness were associated with a significant decrease in mineral apposition rate in single Pkd1+/Δ mice compared with age-matched control (Fig. 2C).
Main bone changes were observed in metaphysis, with significant reductions in bone volume fraction (BV/TV), bone surface density (BS/TV), trabecular number (Tb.N) and volumetric bone mineral density (vBMD) whereas trabecular factor (Tb.Pf) significantly increased.
Micro-CT analysis of the distal femur revealed approximately 45%, 30%and20%0% reductions in bone volume fraction (BV/TV) in Nrf2−/− mice compared to controls at 3, 6 and 8 weeks of age, respectively.
We observed 45%, 30%and20%0% reductions in bone volume fraction (BV/TV) in Nrf2−/− mice compared to controls at 3, 6 and 8 weeks of age, respectively, so it is entirely possible that in the time between 8 and 12 weeks of age, the Nrf2−/− mice may overshoot control animals in attaining their own peak bone mass.
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