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CPP challenge was best represented by relative CPP reduction during the first minutes of SAH but not by peak ICP.
Both studies found a larger symptom reduction during the first two weeks of treatment than during consecutive weeks.
Both the intervention group and the control group showed substantial substance use reduction during the first 12 months.
PSY1 mRNA levels, in stressed leaves, underwent to a minimum reduction during the first 2 h to then returned to the initial level at 5 h.
For irinotecan, six patients in cohort 1 and one patient in cohort 2 required dose reduction during the first two cycles of treatment.
Biomarkers evaluated in this study poorly predict outcome although a reduction during the first 24 hours of PCT is associated with a better outcome.
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Maggioni et al. Reported an absolute improvement during the first trimester, with a further reduction during the second and third ones [5], a data that has been confirmed by more recent studies [9, 13].
4. For patients with more than one dose reduction during the first-line treatment, the reasons for each dose reduction are included.
Dose-limiting neurotoxicity, including hand foot syndrome, was not encountered during dose escalation and only one patient had grade 3 neurotoxicity at the MTD that required a dose reduction during the second treatment cycle.
One patient declined to receive the second infusion because of grade 2 nausea, two patients received a 25% dose reduction during the second infusion due to GI toxicity and in two cases the second infusion was interrupted after 3 days, one due to grade 3 thrombocytopenia and one due to venous access complications.
The relevance of this finding comes from the direct correlation between the hand area activation and contemporaneous pain (i.e. pain experienced during scanning), and is emphasized by the fact that, with significant pain reduction during the second scanning session, no such abnormal activation was elicited.
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