A 6-week, double-blind, placebo-controlled pilot study of Prazosin for the treatment of alcohol dependence reported a significant reduction in drinking behavior in actively drinking alcohol dependent patients (Simpson et al. 2009).
Results from the trial are promising, with problem drinkers who were provided access to the CYD displaying a six to seven drinks per week reduction in drinking compared to controls (a 30% reduction in typical weekly drinking).
There has been a reduction in drinking among young people in Norway in recent years, but still consumption and drinking into intoxication are widespread.
The lead author, Alexander C. Wagenaar of the University of Florida, said the reduction in drinking had been found throughout the population, among social drinkers and problem drinkers alike.
Using a difference-in-differences methodology, we find a reduction in drinking and smoking for 16 year olds.
Both Intra-posterior-VTA administration of THIP and systemic administration of the drug was also associated with an estrous cycle dependent reduction in drinking behavior.
The actual content of the control group procedure itself was not predictive of reduction in drinking, nor were a range of other candidate variables including setting, the exclusion of dependent drinkers, the collection of a biological sample at follow-up, and duration of study.
When compared to standard "state of the art" general education (or no intervention), the students who received video training on the risks of low alcohol sensitivity, and had low LR themselves, showed the greatest reduction in drinking over a 1-year period.
Arsenic is an environmental hazard and the reduction of drinking water arsenic levels is under consideration.
The lack of a placebo group makes it difficult to assess the contribution of Naltrexone Depot to the reduction in drinking.
