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The dashed line appearing in each diagram represents the lower (reducing) stability limit of H2O.
Application of the solution to a typical field operational situation has demonstrated that thermal osmosis can significantly impact formation pore pressure, thereby reducing stability.
The C609T SNP causes a proline to serine mutation at position 187 [ 7], allowing ubiquitination of NQO1 and reducing stability of the protein [ 8].
Specific mutational effects included N33A in TMD1 causing an increase in γ-secretase complexes at the cell surface and a modest decrease in stability and the previously unreported I53A mutation in the loop region reducing stability 10-fold and proteolytic activity by half.
First, at higher folding stabilities, most arising mutations are neutral and do not have tangible effects on fitness (i.e., Pnat): A highly stable protein (e.g., Δ G < −9 kcal/mol) is still "stable enough" after a typical mutation reducing stability by 1 kcal/mol.
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Recombinant expression of the corresponding protein in Escherichia coli resulted in a protein with reduced enzymatic activity and reduced stability towards denaturants in vitro.
Alternatively, the reduced activity of the monomer may simply be a consequence of its reduced stability or of perturbation of the active site geometry.
"Enlargement is a more practical option than promotion and relegation which would reduce stability," Morariu said.
"And there is a tyranny in smaller numbers that reduces stability in certain situations".
The movement faults that a patient presents with – eg reduced glute activation or reduced stability at the pelvis – will form the basis of treatment.
By substitution we obtain another form of the reduced stability condition: D > W 0 − M r.
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