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While a certain level of response variability may serve computational purposes [13], [14], reducing response variability using such an adaptation rule could prevent runaway variability that would lead to perceptual errors [15].
For control subjects, the "rise time regulation" strategy or variations thereof have been suggested to help in reducing response variability[ 16, 22, 23].
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10.7554/eLife.09652.013 Figure 2. Paracrine communication reduces response variability during wounding.
To reduce response variability, the dot size varied with eccentricity.
Local averaging using paracrine signaling reduces response variability in a communication distance dependent manner.
Long-term pre- and postsynaptic plasticity reduces response variability of receptive fields.
Indeed, the CV for Ca2+ wound response shows statistically higher variability than ERK wound response indicating that paracrine communication reduces response variability during initial wound response.
In the case that cellular coordination is beneficial, we anticipated that the ERK response within groups of higher cellular density, that is cells have increased communication ability, would have reduced response variability than cell clusters with decreased communication ability.
We now clarify that our data was collected in an in vitro setting in the Abstract as well as within the main text (subsection "Paracrine signaling reduces response variability" and Discussion, second paragraph).
A recent study has highlighted that chronic neck patients increase their movement time and use alternative control strategies in order to reduce response variability and be as accurate and consistent as possible in their performance [ 37].
Population averaging due to paracrine communication can arbitrarily reduce cellular response variability.
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