Exact(8)
Delivery of RNAi-based gene silencing through live attenuated vaccines for reducing replication of pathogenic viruses is a novel approach for the control of infectious diseases.
These results, together with the previous observation that c-Myc overexpressing cells show an increased number of replication foci [1], suggest that c-Myc may increase the number of active replication origins, thus reducing replication timing.
With respect to CHPV, efficacy of P-2 siRNA in reducing replication was 2logs at 24 hr and 1log at 48hr (p<0.05) as evidenced by plaque assay and real time one step RT-PCR (Fig 2d).
APS was the most effective inhibitor of HCVcc replication, reducing replication by 500 fold at a concentration of 50 μM.
Mutations in both of these genes cause a reduction in the mtDNA nucleotide pooling, reducing replication efficiency.
Further, down-regulation of HDAC3 mimics actions of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA, vorinostat) in reducing replication fork velocity and increasing origin firing at sites of replication, likely due to chromatin changes [ 77].
Similar(50)
We can reduce replication costs by only replicating system volumes because a patch mainly affects the OS or middleware of system volumes.
The I86M mutation of WSN PA subunit also reduced replication and transcription (Figure 6B and C), although the reduced level of cRNA was not statistically significant.
This reduced replication of the CVA21 virus in normal muscle tissue and resulted in reduced muscle toxicity without compromising the tumor cell-killing ability [8].
Inhibition of cell growth and reduced replication potential.
In addition, rDEN3Δ30/31 had reduced replication in Toxorynchites mosquitoes following intrathoracic inoculation.
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