XTENylated proteins and peptides are typically characterized by enhanced solubilities and reduced propensities for aggregation.
Targeted covalent inhibitors exhibit slow target offset, increased binding efficiency and potency, enhanced selectivity, reduced propensity for target-based drug resistance and prolonged pharmacodynamic effects.
Also, the coefficients computed from scrambling tests (a(Q 2)) have in all cases values inferior to 0.4, indicating reduced propensity to chance correlation.
Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes.
Although there is emerging evidence that correction of hypovitaminosis D may reduce propensity for falling [111], its relative contribution to fall risk reduction and the appropriate dosing regimen are uncertain [117].
For example, cells with a gain of chromosome 20q11.1-11.2 had a significantly reduced propensity to differentiate down the hematopoietic lineage and in the neural differentiation experiments the variant cells displayed more immature phenotypes along the differentiation trajectory than their wild-type controls (Werbowetski-Ogilvie et al., 2009).
Ligands that promote endocytosis of the MOR have a reduced propensity to cause antinociceptive tolerance compared to morphine which does not [41] [43] and see Figure S1A).
Apart from a strongly reduced propensity to bind microtubules, non-phosphorylated wild-type Eg5 as well as a non-phosphorylatable Cdk1 mutant of Eg5 are mechanochemically functional as judged by their microtubule gliding activity in vitro.
Sequence analysis of NEDD1 suggests that residues 635 642 have a reduced propensity to form a helix (Figure 2B) and analysis of the CD data at 222 nm predicts that the purified CTD protein is only 70% helical (222 value of -35 000 degrees cm2 dmol−1 was taken to correspond to 100% helix, see methods).
Randomly methylated CD variants showed reduced propensity to aggregate and enhanced solubility properties.
This study provides evidence of a link between primary care supply and reduced propensity for cesarean section.
