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Rituximab inhibits the B-cell function, thus reducing presentation of autoantigen to T-cells and theoretically secondarily preventing B-cell expansion and islet autoantibody production.
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Reduced presentation of Lpl at the lumenal side of capillaries could explain the phenotype of Col18a1−/− mice [30].
Both inhibitors markedly reduced presentation of CII to both T cell hybridomas.
We demonstrated that exposure to live or heat-killed S. Typhimurium (HKST) led to reduced presentation of peptide and native Ag to type A T cells.
Infection of bone marrow-derived dendritic cells (BMDCs) with Salmonella enterica serovar Typhimurium (S. Typhimurium) reduced presentation of antigen to Type A T cells but enhanced presentation of exogenous peptide to Type B T cells.
However, many viruses, including poxviruses [ 3, 11], evade the T cell-mediated immune response, primarily by decreasing the levels of surface MHC I, thus reducing the presentation of pathogen-derived antigens [ 12] to escape cellular immunosurveillance mechanisms [ 13].
These results demonstrate that the inhibition of secretion observed in poliovirus-infected cells substantially reduces the presentation of new antigens on the cell surface.
In agreement with the results of antigen uptake shown in Fig. 3, the treatment of splenic CD11c+ cells with DMA significantly reduced antigen presentation of liposomal antigens to both CD4+- and CD8+ T cells as evaluated by T-cell activation (Fig. 5).
20, 23 These combined effects would potentially reduce the presentation of myelin-specific antigens.
Ideally an intervention to reduce delayed presentation of breast cancer would promote early help-seeking behaviour by patients at high risk of having cancer, but would not promote anxiety amongst people at low risk.
In an additional control experiment, we verified that reduced endogenous presentation of the SQLLNAKYL epitope was not due to an inhibition of MHC class I expression by the drugs used to clear the parasites.
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