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PDK1 drives ROCK-I to the plasma membrane where it stimulates actomyosin phosphorylation and contraction, while Rnd3 can bind to ROCK-I and inhibit its activity, reducing motility.
Given that bacterial motility and/or cell surface proteins are often required for infection or retention of bacteria, blocking these cell surface binding sites and/or reducing motility of the bacteria will reduce the infectivity of the organism.
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This includes reduced motility and muscle deterioration, which are seen in other organisms, including humans.
However, by 2 weeks of age, they presented a significantly reduced weight compared with their littermates (4.1±0.8 g versus 8.7±0.5 g) and reduced motility (Figure 2a; Supplementary Video S1).
Inhibition of the sepn1 gene by injection of antisense morpholinos does not alter the fate of the muscular tissue, but causes muscle architecture disorganization and greatly reduced motility.
In withdrawal experiments, planarians exposed to sucrose (1%) for 60 min and then tested in water for 5 min displayed reduced motility compared to water controls.
In addition, expression of MAL reduced motility and resulted in a redistribution of lipid raft components in MCF10A cells.
A painless swelling occurs on the affected joint causing reduced motility, and is sometimes associated with an articular deformity.
After 24 h of treatment, the difference in HSC-T6 cell migration between 62 µmol/L MD-1 and 128 µmol/L MT was not significant, but both significantly reduced motility compared to control (Fig. 2B; P < 0.05).
Depletion of ETS factors in vitro reduces motility and invasiveness.
This can explain why HDI but not LDI lineages have evolved towards reduced motility.
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