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Optimizing the dosage of CDDO-Im and/or the administration schedule might help in reducing lethality while preserving the efficacy of the drug against CLL/SBL.
It seems also that poststroke serum IGF-1 levels are correlated with outcome from ischemic brain injury, with its higher levels reducing lethality [ 34].
The recently demonstrated clinical efficacy of APC in reducing lethality in patients with severe sepsis [ 33] further emphasizes the importance of the coagulation signaling mediated regulation of inflammatory balance in clinical settings.
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Rearing these mutant animals at reduced temperatures decreased intracellular accumulation, increased secretion and was sufficient to reduce lethality for some mutations (21).
As shown in Fig. 5a, the Mecp2 Δ3–4/Y mice presented significantly reduced lethality compared to Mecp2-null animals.
In vivo, the RMAE markedly reduced lethality, hemorrhage, edema, muscle and liver toxicities induced by Cc venom.
We predict that reduced lethality through poor SIT methods or imperfectly efficacious vaccines will impact efforts to control disease spread.
The number of bullets in an assault weapon -- the magazine size -- could also be reduced to reduce lethality.
Furthermore, the intraperitoneally injected OMVs (25 µg) caused delayed and reduced lethality in CD14−/− mice than in wild-type mice (Fig. 6C).
Similar to full-length BRCA1, expression of the BRCT construct in WT yeast resulted in significant but slightly reduced lethality (relative survival fraction = 0.21±0.06; ±1 SE).
Other investigators also showed that the intranasal challenge with a sub-lethal dose of the bacteria has shown that MAbs against PS, LPS, and glycoproteins of BP and/or BM significantly reduce lethality of infections in mice.
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