The neurogenic inflammation induced by substance P and CGRP may, however, aid the translocation of telcagepant into the CNS through increased vascular permeability and reduced integrity of the blood-brain barrier and thus enable interaction with CGRP receptors on the abluminal surface of vessels as well as on perivascular nerves and higher cortical structures.
The decreased functional connectivity between thalamus, many cortices, and basal ganglia indicated reduced integrity of thalamic resting-state network in MHE.
A similar relationship between frontal connectivity and executive function has been observed in studies of normal ageing, where, in older adults, reduced integrity in tracts connecting frontal regions predicts executive dysfunction (O' Sullivan et al., 2001; Davis et al., 2009; Perry et al., 2009).
However, the developments of crystallinity and lamellar size occur at the expense of reducing the integrity of the molecular network.
Constitutively expressed and secreted mesophilic cellulases can also inhibit normal plant growth, by reducing the integrity of the cell wall and therefore leaving the plant vulnerable to environmental stresses [ 13].
It would "impact negatively on the outstanding universal value of the property" and "reduce integrity of key natural attributes".
The regulations already in place around data integrity and privacy are intended to prevent breaches and the behaviors that could violate consumer privacy or reduce the integrity of information assets.
These defects occur simultaneously with reduced neuronal integrity.
10 µM sunitinib preferentially reduced ER integrity, preceding visual decreases in ΔΨm and transmitted light, respectively.
Broadcasters say attempts to add hundreds of these low-power stations in radio markets nationwide will reduce the integrity of the radio spectrum and cause unacceptable distortion.
Also, keep in mind that when the undercarriage and frame rust, it can eventually lead to safety problems and reduced structural integrity.
