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Hypercapnic acidosis appears to inhibit pulmonary epithelial wound healing by reducing cell migration via an NF-κB-dependent mechanism.
The extract also inhibited the inflammatory process induced by subcutaneous carrageenan injection by reducing cell migration, protein extravasation, and TNF-α production.
Decreasing cell proliferation and reducing cell migration into the smooth muscle layer are two mechanisms which could limit the accumulation of smooth muscle in airway remodeling [ 35].
QSOX1 also reduces the invasive potential of cells by reducing cell migration and decreases the activity of the matrix metalloproteinase, MMP-2, involved in these mechanisms.
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication.
We previously showed that statins exhibit antitumor effects in vitro, inducing apoptotic cell death, reducing cell migration and invasion capacities and strengthening cytotoxic effects in combination with standard drugs.
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This aspect together with the downregulation of different chemokines may suggest a reduced cell migration and therefore a reduced andothelial cell homing.
Under these conditions, the level of reduced migration (55%) was similar revealing that miR-21 reduces cell migration independently of its effect on proliferation (Figure 2H).
Reduction of miR-411-5p/3p expression also reduced cell migration (Fig. 4g).
Prior work using LN 229 glioblastoma cells as a model system had found reduced cell migration arising with ATRX deficiency41.
In addition, Kank proteins diminish the talin-actomyosin linkage, which curbs force transmission across integrins, leading to reduced integrin-ligand bond strength, slippage between integrin and ligand, central adhesion formation and sliding, and reduced cell migration speed.
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