Sentence examples for reducing cell differentiation from inspiring English sources

However, more recent reports showed some conflicting results that CaP coating suppressed the activity of osteoblasts such as lowering cell proliferation and reducing cell differentiation [ 26, 27]. Lee and his colleagues demonstrated that osteoblasts had a lower proliferation rate on apatite surface compared to tissue culture dish [ 28].

Furthermore, hERG expression is implicated in enhanced cell proliferation, invasiveness, lymph node dissemination, and reduced cell differentiation and prognosis.

In ES cells, HIF2- α increases Oct-4 expression, reduces cell differentiation and may promote tumor formation.

In a different context, hyperglycemia was shown to lead to myocyte cell death (20) and to reduced cell differentiation in endothelial progenitor cells that is indicative of advanced cell senescence (21).

Whether AMPK executes its different roles simultaneously in response to its activation remains to be determined, but there are indications that AMPK reduces cell differentiation of myoblasts, thereby reducing hypertrophy, without necessarily accelerating protein degradation (Fulco et al. 2008).

How to surpass in vitro stem cell differentiation, reducing cell manipulation, and lead the in situ regeneration process after transplantation, remains to be unraveled in bone tissue engineering (bTE).

The vitamin D receptor binds the active form of 25(OH D (i.e., 1,25 dihydroxyvitamin D (1,25(OH)2D)) in the nucleus of breast epithelial cells, thereby reducing cell proliferation, and increasing cell differentiation, autophagy and apoptosis [ 44].

We observed that the stiffness of chondroid cells increased continuously in the late stage differentiation, reducing cell deformability and perhaps causing cell degeneration.

Therefore, we found scaffold stiffness had different effects on differentiation and cell number whereby the increased cell-mediated contraction facilitated by the less stiff scaffolds positively modulated osteoblast differentiation while reducing cell numbers.

We demonstrate for the first time that tankyrase inhibition triggers reduced cell growth and differentiation of OS cells.

Despite these inhibitory activities against recombinant AKR1C3 protein in biochemical assays, our in vitro cell data indicates that, at least in AML and CLL, a selective AKR1C3 agent has no or little anti-neoplastic activity, as none of the inhibitors reduced cell proliferation, increased differentiation or induced apoptosis in our cell models.