Sentence examples for reducing affinity for from inspiring English sources

These mutations result in a compromised SPT enzyme, severely impacting PLP binding, reducing affinity for the L-serine substrate, and causing catastrophic effects on catalytic activity.

The RH substitutions therefore changed the protein's preferred DNA binding sites by exploiting a preexisting latent affinity for a moderate-affinity RE and dramatically reducing affinity for the ancestral RE.

W430A had strongly reduced affinity for tetramethylammonium.

A missense mutation in the G-box reduces affinity for the centriolar shuttling protein STIL and causes primary microcephaly.

Several neurokinin NK1 receptor antagonists currently being developed for anxiety and depression have reduced affinity for the rat and mouse NK1 receptor compared with human.

While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.

By contrast, the U state has a greatly reduced affinity for both metals under these conditions [6], [7], [24], [25].

TEM-33, also called inhibitor resistant TEM 5 or IRT-5, has a reduced affinity for β-lactamase inhibitors.

The R69A MtBPL has similar affinity for biotin as that of wild type in contrast to R118G EcBirA which exhibited reduced affinity for biotin.

This could be explained if the Q169 mutants have reduced affinity for the nucleotide that would be incorporated at this position.

Alternatively, isolated CbfA-CTD may have a reduced affinity for its target promoter sequences and may be unable to displace endogenous CbfA.