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It has been reported that inhibiting either SelK or SelH expression significantly reduces viability in embryos [15].
This shorter time to detection is surprising due to the paucibacillary nature of CSF samples and may be because the NALC-NAOH decontamination of sputa samples reduces viability of the TB bacilli- prior decontamination is not required for CSF samples.
More difficult to reconcile with our hypothesis of dispensability of selenoproteins in Endopterygota are the experiments in which inhibition of either SelK or SelH expression significantly reduces viability in D. melanogaster embryos [14], [52].
Furthermore, we found that treatment with the CK1ε inhibitor IC261 at 1 or 2 uM reduces β-catenin transcriptional activity by approximately two-fold in MCF7 cells, supporting the hypothesis that IC261 reduces viability at least in part through inhibition of Wnt/β-catenin signaling (Fig. 5A).
However, the mutation (or a hitchhiking mutation/s) reduces viability by an unpredictable mechanism.
Curcumin treatment reduces viability of all cell lines within 24 h of treatment in a 5 50 μ M range.
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Hybrid individuals, which carry genes combined from the two gene pools, will therefore experience reduced viability or fertility.
However, MoS2-PEG-PEI exhibited slightly reduced viability mainly because it was positively charged.
Moreover, MCNs at similar concentrations reduced viability of J774A.1 macrophages and lung epithelial A549 cells.
As seen in Fig. 4, cisplatin treatment of Raji cells reduced viability by >50% at 24 h of induction.
The HA treatment groups in the presence of light showed greater reduced viability count compared to darkness exposure groups.
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