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The underestimation of Simple forms reduces the specificity of the test; however, it makes possible to have a high sensibility, reducing the number of false positive cases.
Although this probeset could be used to construct a classifier with a reasonably large margin, the presence of a sample of normal tissue with expression close to the cancer group drastically reduces the specificity of a classifier based upon this probeset.
Inclusion of individuals with autoimmune diabetes and GCK-MODY reduces the specificity of the hs-CRP threshold of 0.4 mg/l to 63%.
This increases the rate of false-positives and thus reduces the specificity of method (1) compared with method (2), which explains the metaregression findings.
This finding may be explained by the fact that treating prevalent cases as incident cases reduces the specificity of the test, which again leads to a misclassified outcome.
The overlap of clinical signs such as leg swelling reduces the specificity of this tool and the low prevalence adversely affects the positive predictive value of a "high risk" assessment.
Similar(51)
The use of surrogate tissue-specific markers can reduce the specificity of the assays and give rise to a clinically unacceptable false-positive rate.
The authors proposed that AV-45 ROI SUVr included local non-specific white matter uptake, reducing the specificity of the findings compared to PiB in patients.
Despite this, in the case of the energy asymmetry method, saturation of signals contributes to reduce the specificity of the parameter and a slight degradation of the resolution can be expected at the boundaries of the DOI range.
Another limiting factor to the use of 18F-FDG for assessment of cardiac sarcoidosis is that both inflammation and myocardial ischemia can increase glucose utilization and can further reduce the specificity of myocardial 18F-FDG uptake.
Large necrotic tissues could have more false-positive uptakes of 11C-MET through variable factors mentioned above than small necrotic tissues, which could reduce the specificity of 11C-MET PET/CT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com