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The drawbacks with this approach are twofold; I would not know whether results generalize to other clutch sizes, and this approach reduces sample size and thus the power to observe a real effect.
However, matching reduces sample size because those women whose exposures cannot be matched are excluded.
The Item-Improved HAQ reduces sample size by one-third, compared with its parent.
Omitting individuals with missing data, and conducting a so-called complete-case analysis not only reduces sample size but can also lead to invalid results.
This modification reduces sample size losses and facilitates inclusion of a sicker portion of the population in whom early mortality is common.
One suggested approach is to use RNFL thickness in the clinically unaffected fellow eye as a baseline measure, which reduces sample size by around one-third (Henderson et al., 2010).
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In 3DISCO, dehydration can reduce sample size by up to 50%.
Reducing sample size requirements for future ALS clinical trials with a dedicated electrical impedance myography system.
There is increased interest in using alternative end points in clinical trials to shorten trial duration and reduce sample size.
And reducing sample size is a particular advantage in developing countries, where noninvasively gathering small amounts of fluids avoids the need for syringes, which can be hard to clean and dispose of.
Double sampling ¯¯¯X control chart (DS) which is a Shewhart-type chart can reduce sample size and detect small process shift fast.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com