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Depletion of ETS factors in vitro reduces motility and invasiveness.
Fibroblasts move by extending lamellipodia at the leading edge and formation of fine actin structures at the leading edge causes retrograde movement [39]; sequestration of Ena/VASP to mitochondria increases whereas its targeting to cell membrane reduces motility [38].
WNT stimulates tumor cell motility; conversely sFRP1-mediated WNT pathway blockade reduces motility.
Significantly it was shown that the interaction between these two proteins, reduces motility and metastatic ability of S100A4 transformed cells (Wang et al, 2005).
The adhesion-contractility balance is impaired at the two extreme conditions where too little adhesion precludes a cell from generating sufficient adhesions for locomotion; hence further lowering of contractility even by subtotal inhibition of MLC further reduces motility.
We find that OM has little impact on βMys actin-activated ATPase, in agreement with prior results, or its 3 unitary step-sizes but dramatically reduces motility velocity and affects the relative step-frequency.
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This includes reduced motility and muscle deterioration, which are seen in other organisms, including humans.
However, by 2 weeks of age, they presented a significantly reduced weight compared with their littermates (4.1±0.8 g versus 8.7±0.5 g) and reduced motility (Figure 2a; Supplementary Video S1).
Inhibition of the sepn1 gene by injection of antisense morpholinos does not alter the fate of the muscular tissue, but causes muscle architecture disorganization and greatly reduced motility.
In withdrawal experiments, planarians exposed to sucrose (1%) for 60 min and then tested in water for 5 min displayed reduced motility compared to water controls.
In addition, expression of MAL reduced motility and resulted in a redistribution of lipid raft components in MCF10A cells.
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