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ART dramatically prolongs life and reduces infectiousness for people with HIV.
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The antiviral reduces infectiousness of individuals by 60% [ 46].
Providing treatment within 48 hours of symptom onset to a proportion of cases arising in the absence of prophylaxis also reduces infectiousness (et) [28] [29].
Although antiretroviral therapy (ART) prolongs life and reduces infectiousness, in some contexts, it has been associated with increased sexual risk taking.
We assumed that treatment would reduce infectiousness of a symptomatic individual by 66% [ 38].
For TasP, willingness to test for HIV, be linked to care, and adherence to cART to reduce infectiousness all require behavioral support.
Being on treatment will still reduce infectiousness even if you have more than one partner, but you could not rely on it to prevent transmission in the same way that an exclusive couple might.
The treatment of the index case was assumed to reduce infectiousness by 70% [8] [11], whereas AVP was assumed to reduce susceptibility to infection by 30%, infectiousness by 70%, and the occurrence of symptomatic disease by 60% [10].
Because the trial's intervention was intended to reduce infectiousness in the HIV-1 infected partner, only linked transmissions were relevant to ascertainment its efficacy.
The infection profile of a symptomatic individual was assumed to last for 6 days as follows: a 0.5 day latent period (with Inf(I i ) set to 0) is followed by 1 day asymptomatic and infectious, where Inf(I i ) is set to 0.5; then 2 days at peak infectiousness (with Inf(I i ) set to 1.0); followed by 2.5 days reduced infectiousness (with Inf(I i ) set to 0.5).
Treatment of the index case was assumed to reduce infectiousness by 70% [ 2- 6], whereas antiviral prophylaxis was assumed to reduce susceptibility to infection by 30%, infectiousness by 70%, and the occurrence of symptomatic disease by 60% [ 3].
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