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By forming glutathione adducts, cisplatin is detoxified, which reduces efficacy.
One participant stated that prolonged usage of medicines reduces efficacy Rashida: Anything stops having an effect.
Every time the dose is delayed 12 h after starting emergency contraception treatment it reduces efficacy by about 50% [ 14].
It not only reduces efficacy of the treatment, but wastes healthcare resources in prescribed pills not taken, extra consultations, referrals, investigations and hospital admissions [ 7, 8].
The best support for this hypothesis is the now definitive conclusion that HER2 gene amplification reduces efficacy of endocrine approaches to ER-positive breast cancer.
Rog-A shows no desensitization after a brief spiradoline pretreatment, while the same treatment reduces the potency of spiradoline at Rog-μA and reduces efficacy at Rog-μ.
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The reduced physiological reserve and reduced efficacy of pre-oxygenation in intensive care patients makes their intubation particularly dangerous.
Pyrethroids are known to have reduced efficacy when used during warm temperatures above 65oF.
Marcombe, S. et al. Reduced Efficacy of Pyrethroid Space Sprays for Dengue Control in an Area of Martinique with Pyrethroid Resistance.
Lipoplatin is a new liposomal cisplatin designed to reduce cisplatin toxicities without reducing efficacy.
The Antarctic Bottom Water – the coldest and most oxygen-rich deep-water body on earth – ventilates the world's seas, and excessive fishing or offshore drilling will decrease its oxygen content, reducing efficacy.
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