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Microtubule proliferation reduces contraction by impeding sarcomeric motion; modulation of sarcoplasmic reticulum Ca2+ release may also be involved in this effect.
By regulating cytoskeleton gene expression, FGF2 potentially promotes cell migration in the wound site, and reduces contraction that leads to the favorable pro-regenerative outcome.
Although β1AR is only able to interact with Gs, β2AR can bind both to Gs and to the inhibitory Gi protein; β2AR-Gi activation reduces contraction via both cAMP-dependent and -independent mechanisms.
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ERAs prevented the contractile response to low ET-1 concentration, but failed either to reduce contraction when ET-1 levels were high or to relax uterine arteries pre-contracted with ET-1, even when they were combined.
Also, the addition of bioactive glass has reduced contraction of the PLGA/collagen scaffold in contact with the culture medium (data not shown).
The engineered tissues containing cells transfected to overexpress one of the has isozymes had significantly increased retention of hyaluronan within the scaffold; elevated hyaluronan secretion into the culture medium (all but has-2); reduced contraction; reduced collagen density; and significantly altered material properties compared to the LXSN controls.
Reduced contraction strength in three failing hearts was confirmed by tagged MRI and tissue was obtained directly from the operating theatre (e.g. Figure 1).
Following pathogen elimination, the number of specific effector CD8+ T cells is drastically reduced (contraction phase) and the establishment of a long-lived population of memory T cells responsible for perpetuating immunity against re-infection takes place.
Alternatively, nRHO-1(G14V) expression in pharyngeal motor neurons may alter more than ACh release, for example neuropeptides and octopamine that can both reduce contraction of the pharyngeal muscle [49].
The mechanism(s) for this reduced contraction requires further investigation.
Compounds that reduced contraction to less than 0.6 at 1 μ M also reduced contraction at 10 μ M but that the converse was not necessarily true.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com